CPC Class C12Q

The invention(s) include systems and methods for receiving and processing agriculture-associated samples with sample processing architecture structured to rapidly return outputs characterizing effects of agriculture inputs and practices over time. Control instructions based upon outputs of the systems and methods are then executed for maintaining or improving performance of crops and agriculture sites (e.g., in relation to yield, in relation to nutrient characteristics) in a sustainable manner (e.g., environmentally sustainable manner). System and method outputs can further be used to affect modifications to product treatments generated by associated manufacturers.

The present invention relates to plants having the activity of a haploid inducer comprising mutations in certain regions of the KINETOCHORE NULL2 (KNL2) protein in a plant, in particular within the SANTA domain. Provided are methods of generating haploid cells and doubled haploid cells as well as corresponding plants and plant parts. The present invention also relates to a method for identification of a plant in a plant population, wherein the plant has at least one mutation in the KNL2 protein, in particular within the SANTA domain, which confers activity of a haploid inducer. Further provided is a set of oligonucleotides for the identification of a plant having activity of a haploid inducer.

Disclosed is a biosensor. The biosensor comprises: an electrode; and a polymer structure disposed on the electrode and formed of poly-5,2′:5′,2″-terthiophene-3′-carboxylic acid (pTTCA), wherein an enzyme is present in a state of covalently binding with pTTCA inside the polymer structure.

Compositions and methods for the treatment of malignancy are disclosed.

Computational and functional analysis identified the neuropeptide receptor Nmur1 as selectively expressed on Type 2 innate lymphoid cells (ILC2s). While both IL-33 and IL-25 promote ILC activation in vivo, IL-33 induces robust ILC proliferation, whereas ILCs activated with IL-25 do not proliferate as robustly and up-regulate Nmur1 expression. Treatment with neuromedin U (NMU), the neuropeptide ligand of Nmur1, had little effect on its own. Co-administration of IL-25 with NMU, however, dramatically amplified allergic lung inflammation and induced the proliferation and expansion of specific ILC2 subsets, characterized by a molecular signature unique to pro-inflammatory ILC2s. The results demonstrate that Nmur1 signaling strongly modulates IL-25-mediated ILC2 responses, resulting in highly proliferative pro-inflammatory ILCs, and highlights the importance of neuro-immune crosstalk in allergic inflammatory responses at mucosal surfaces.