CPC Class C12Q

The present invention relates to a Lactuca sativa seed designated 41-692 RZ. The present invention also relates to a Lactuca sativa plant produced by growing the 41-692 RZ seed. The invention further relates to methods for producing the lettuce cultivar, represented by lettuce variety 41-692 RZ.

The invention relates to the soybean variety designated 01068883. Provided by the invention are the seeds, plants and derivatives of the soybean variety 01068883. Also provided by the invention are tissue cultures of the soybean variety 01068883 and the plants regenerated therefrom. Still further provided by the invention are methods for producing soybean plants by crossing the soybean variety 01068883 with itself or another soybean variety and plants produced by such methods.

The present invention relates to a Solanum lycopersicum seed designated 72-001 RZ. The present invention also relates to a Solanum lycopersicum plant produced by growing the 72-001 RZ seed. The invention further relates to methods for producing the tomato cultivar, represented by tomato variety 72-001 RZ.

The disclosure relates to methods and compositions including p38 kinase inhibitors and agents that regulate expression of DUX4 and downstream genes including but not restricted to ZSCAN4, LEUTX, PRAMEF2, TRIM43, MBD3L2, KHDC1L, RFPL2, CCNA1, SLC34A2, TPRX1, PRAMEF20, TRIM49, PRAMEF4, PRAME6, PRAMEF15, or ZNF280A. Methods useful for treating a disease associated with abnormal DUX4 and downstream gene expression (e.g., Fascioscapulohumeral muscular dystrophy) are disclosed.